DNA Fragmentation and DSB correlation Induced in Human Fibroblasts by Accelerated 56Fe Ions of Differing Energies
نویسنده
چکیده
HZE particles from space radiation raise an important protection concern during longterm astronauts’ travels. Although these particles are less abundant than protons, they are more effective in damaging biological systems. It is thought that this is due to the frequent production of spatially correlated DNA damaged sites, particularly double strand breaks (DSB), since this correlation can strongly affect the repair capability of the cells.
منابع مشابه
Cell killing and chromatid damage in primary human bronchial epithelial cells irradiated with accelerated 56Fe ions.
We examined cell killing and chromatid damage in primary human bronchial epithelial cells irradiated with high-energy 56Fe ions. Cells were irradiated with graded doses of 56Fe ions (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at Brookhaven National Laboratory. The survival curves for cells plated 1 h after irradiation (immediate plating) showed little or no shoulder. H...
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